Article

Phase-resolved transcriptomic bottlenecks in peptide cancer vaccine response

2026-08-26

Abstract excerpt

<h4>Background: </h4> Peptide cancer vaccines can elicit antigen-specific immunity, but peripheral immunogenicity often does not translate into durable tumor control. <h4>Methods:</h4> We analyzed transcriptomic profiles across three public human peptide-vaccine cohorts: C1/GSE278476, a MUC1 plus Poly-ICLC PBMC RNA-seq cohort with ordered anti-MUC1 IgG response classes; C2/GSE85698, manufactured dendritic-cell vac...

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Literature Corpus work: b0a3d78e-a28d-5571-b686-6df6f7f2c50b
DOI: 10.64898/2026.08.21.746349

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