Article

Variance-based Decomposition of Inter-patient Transcriptomic Heterogeneity Reveals Recurrent Modes of Therapeutic Antigen Biology Across 33 Cancer Types

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>Background Inter-patient expression heterogeneity is not merely statistical dispersion but a structured biological signal encoding distinct therapeutic antigen states. Current antigen discovery frameworks over-prioritize mean expression and systematically underinterpret this variance structure, potentially obscuring the most clinically actionable targets. We asked whether inter-patient...

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Literature Corpus work: 3a473220-8db4-58b0-8143-969b8dbfff51
DOI: 10.21203/rs.3.rs-9183099/v1

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