Article

A Multi-Omics Computational Pipeline for Systematic Discovery of Retired Self-Antigens as Cancer Vaccine Targets

2026-04-22

Abstract excerpt

<h4>Background</h4> The retired antigen hypothesis, introduced by Tuohy and colleagues, proposes that tissue-specific proteins expressed conditionally during early life or reproductive stages, then silenced in normal aging tissue, represent safe and effective cancer vaccine targets when re-expressed in tumors. To date, discovery of retired antigens has relied entirely on hypothesis-driven wet lab work, limiting t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 634f2c70-c71b-55ee-aaef-8b72370c29b3
DOI: 10.64898/2026.04.20.26351288

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Multi-Omics Computational Pipeline for Systematic Discovery of Retired Self-Antigens as Cancer Vaccine TargetsDOI 10.64898/2026.04.20.26351288Read

Pan-cancer Variance Decomposition Nominates Translationally Actionable Therapeutic Antigen Candidates Across 33 Cancer TypesSemantic proximity Read

NovumRNA: accurate prediction of non-canonical tumor antigens from RNA sequencing dataSemantic proximity Read

CMS4-focused multi-omic integration enhances antigen target identification in colorectal cancerSemantic proximity Read

Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories.Semantic proximity Read

Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoireSemantic proximity Read

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomics demonstrate immunogenicity and tumor suppression in CRC.Semantic proximity Read

TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopesSemantic proximity Read

Targeting Germline BRCA1-Associated Breast Cancer Through Transcriptome-Guided ImmunopreventionSemantic proximity Read

Identification of novel tumor antigens and immune subtypes in breast cancer patients for mRNA vaccine developmentSemantic proximity Read

Variance-based Decomposition of Inter-patient Transcriptomic Heterogeneity Reveals Recurrent Modes of Therapeutic Antigen Biology Across 33 Cancer TypesSemantic proximity Read

Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasisSemantic proximity Read

The immunopeptidome from a genomic perspective: Establishing immune-relevant regions for cancer vaccine designSemantic proximity Read