Article

Mitochondrial DNA copy number is associated with cognitive function, cognitive decline, and dementia: a longitudinal study in UK Biobank

2025-04-12

Abstract excerpt

Mitochondria are the principal generators of ATP, playing a crucial role in brain health. Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and has been linked to cognitive function and impairment. However, existing studies are often limited by cross-sectional designs, small sample sizes, or a focus on dementia patients. Using data from 239,070 UK Biobank participants of European ances...

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Literature Corpus work: b09fcaca-48f2-594c-9b62-574b667f6daa
DOI: 10.1101/2025.04.11.25324538

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