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Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty.

GeroScience - 1 Feb 2025

Tian Qu, Zweibaum David A, Qian Yong, Oppong Richard F, Pilling Luke C, Casanova Francesco, Atkins Janice L, Melzer David, Ding Jun, Ferrucci Luigi

Abstract excerpt

Mitochondrial dysfunction is linked to physical impairment and dementia. Mitochondrial DNA copy number (mtDNAcn) from blood may predict cognitive decline and dementia risk, but the effect of somatic mutations or frailty is unknown. We estimated mtDNAcn using fastMitoCalc and microheteroplasmies using mitoCaller, from Whole Genome Sequencing (WGS) data. In 189,566 participants free of dementia at study entry (mean...

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Aged
Dementia
DNA Copy Number Variations
DNA, Mitochondrial
Frailty

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PMID: 39313624
DOI: 10.1007/s11357-024-01355-1
PMCID: PMC11872790

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