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Article

Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase

16 Jul 2019

Abstract excerpt

Zika virus is a positive single-strand RNA virus whose replication involved RNA unwinding and synthesis. ZIKV NS3 contains a helicase domain, but its enzymatic activity is not fully characterized. Here, we established a dsRNA unwinding assay based on the FRET effect to study the helicase activity of ZIKV NS3, which provided kinetic information in real time. We found that ZIKV NS3 specifically unwound dsRNA/dsDNA...

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Identifiers

PMID: 31361901
DOI: 10.1093/nar/gkz650

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