Article

C57 and DBA mouse strains express distinct cocaine avoidance phenotypes in an operant runway independent of differences in striatal dynorphin-enkephalin balance

2025-05-08

Abstract excerpt

<h4>Rationale</h4> Human self-report data and rodent models indicate cocaine can induce negative affect, which may impact future cocaine use severity. Despite this, understanding of the neurobiology driving cocaine avoidance is limited. Within the striatum, the opioid peptides enkephalin and dynorphin are associated with cocaine reward and aversion, respectively. Additionally, striatal dynorphin signaling resulti...

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Literature Corpus work: b05894dd-aa53-5be7-b2e4-138b9d911a37
DOI: 10.1101/2025.05.03.652074

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C57 and DBA mouse strains express distinct cocaine avoidance phenotypes in an operant runway independent of differences in striatal dynorphin-enkephalin balanceDOI 10.1101/2025.05.03.652074Read

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