Article
Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.
Psychopharmacology - 1 Jun 2026
Dickson Price E, Datta Udita, Wilcox Troy D, Auth Ashley A, Ball Robyn L, Dunn Matt, Fisher Heidi S, Klein Alyssa, Leonardo Michael R, Roy Tyler A, Saul Michael C, Bubier Jason A, Gagnon Leona H, Philip Vivek M, Tarantino Lisa M, Jentsch James D, Chesler Elissa J
Abstract excerpt
Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer a powerful method to dissect the biology of this progression from initiation, dose-response, extinction, and cued reinstatement in a controlled, tractable system. However, many...
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