Article

Shifted balance between ventral striatal prodynorphin and proenkephalin biases development of cocaine place avoidance

2025-03-02

Abstract excerpt

Evidence from human self-report and rodent models indicate cocaine can induce a negative affective state marked by panic and anxiety, which may reduce future cocaine use or promote co-use with opiates. Dynorphin-mediated signaling within the striatum is associated with negative affect following cocaine withdrawal and stress-induced cocaine seeking. Here, we used a trace conditioning procedure to first establish th...

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Literature Corpus work: cb25733e-f14d-5e85-aafc-d15619dc1aee
DOI: 10.1101/2025.02.28.640871

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