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Article

Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration.

Neuropharmacology - 1 Jun 2016

Valenza Marta, Picetti Roberto, Yuferov Vadim, Butelman Eduardo R, Kreek Mary Jeanne

Abstract excerpt

The aim of the present study was to investigate alterations in gene expression of opioid system components induced by extended access (18 h) cocaine self-administration and to determine the impact of genetic background in the vulnerability to escalate cocaine intake. Comparing two inbred rat strains, we previously reported that Lewis rats progressively escalated cocaine consumption compared to Fischer rats, in a...

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Identifiers

PMID: 26777278
DOI: 10.1016/j.neuropharm.2016.01.004
PMCID: PMC4894495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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