Article

Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic Mice

2021-07-09

Abstract excerpt

Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals. Human artificial chromosome (HAC) is a precedent chromosomal vector which achieved generation of valuable humanized animal models for fully human antibody production and human pharmacokinetics. While humanized Tc animals created by H...

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Literature Corpus work: b051e259-2125-5c44-a0f4-cd12a4b523be
DOI: 10.21203/rs.3.rs-675300/v1

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