Article

Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration

2025-05-06

Abstract excerpt

<title>Abstract</title> <p>Humanized transgenic mice carrying human genes are useful for research on gene function and disease. Bacterial artificial chromosomes (BACs) that carry human genomic sequences with regulatory elements enable the expression of transgenes at physiological levels <italic>in vivo</italic>. To study complex biological phenomena involving multiple genes, techniques for co-introducing transgen...

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Literature Corpus work: ddc6b8eb-003f-543c-af39-336b61034d85
DOI: 10.21203/rs.3.rs-6525804/v1

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