Article

Germline genetic variants associated with leukocyte-genes predict tumor recurrence in breast cancer patients

2018-05-02

Abstract excerpt

Germline genetic variants such as BRCA1/2 play an important role in tumorigenesis and clinical outcomes of cancer patients. However, only a small fraction (i.e., 5-10%) of inherited variants has been associated with clinical outcomes (e.g., BRCA1/2, APC, TP53, PTEN and so on). The challenge remains in using these inherited germline variants to predict clinical outcomes of cancer patient population. In an attempt t...

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Literature Corpus work: b04ed84d-5483-51d9-b1ec-ddd5820cf82c
DOI: 10.1101/312355

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