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Article

Genomic and transcriptomic evaluation of primary and recurrent luminal B-like breast cancer.

ESMO open - 1 Jun 2026

Li L, Yin G, Liu X, Zhang J, Zhou C, Song P, Zhao L, Zhou W, Huang S, Yu Z

Abstract excerpt

BACKGROUND: Luminal B-like breast cancer (LBBC) constitutes approximately 40% of breast cancer cases and carries a higher risk of recurrence and poorer prognosis than luminal A-like disease. This study aimed to investigate the molecular alterations between primary and recurrent LBBC tumors, elucidate the drivers of LBBC recurrence and identify potential therapeutic targets. MATERIALS AND METHODS: We performed DNA...

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Source

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Identifiers

PMID: 42263480
DOI: 10.1016/j.esmoop.2026.107736
PMCID: PMC13272503

Genes

EGFR
GNAS
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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