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Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients

1 Nov 2019

Abstract excerpt

Abstract Germline variants such as BRCA1/2 play an important role in tumorigenesis and clinical outcomes of cancer patients. However, only a small fraction (i.e., 5–10%) of inherited variants has been associated with clinical outcomes (e.g., BRCA1/2, APC, TP53, PTEN and so on). The challenge remains in using these inherited germline variants to predict clinical outcomes of cancer patient population. In an attempt...

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PMID: 31701019
DOI: 10.1038/s41698-019-0100-7

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