Article

Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease

2024-03-18

Abstract excerpt

Intestinal inflammation continues in a subset of celiac disease (CD) patients despite a gluten-free diet. Here, by applying multiomic single cell analysis to duodenal biopsies, we find low-grade malignancies with lymphoma driver mutations in refractory CD type 2 (RCD2) patients comprise surface CD3 negative (sCD3-) lymphocytes stalled at an innate lymphoid cell (ILC) - progenitor T cell stage undergoing extensive...

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Literature Corpus work: b043294a-62e4-5e15-b0e4-39272a225e9d
DOI: 10.1101/2024.03.17.24304320

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