Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.

doi:10.1053/j.gastro.2026.03.025

Article

Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.

Gastroenterology - 1 Sept 2026

Malamut Georgia, Guégan Nicolas, Carbone Francesco, de Giacomoni Antoine, Ferment Adélaïde, Masson Cécile, Luka Marine, Cording Sascha, Bole Christine, Fumery Mathurin, Matysiak-Budnik Tamara, Bouguen Guillaume, Abitbol Vered, Coriat Romain, Terris Benoît, Burroni Barbara, Beuvon Frédéric, Lhermitte Ludovic, Brouzes Chantal, Duboc Henri, Nion-Larmurier Isabelle, Uzzan Mathieu, Sibon David, Asnafi Vahid, Hermine Olivier, Ménager Mickaël, Cerf-Bensussan Nadine, Levescot Anaïs

Abstract excerpt

BACKGROUND & AIMS: Despite recent advances, refractory celiac disease (RCD) poses challenging questions. In type 2 RCD (RCD2), the lack of response to the gluten-free diet is attributed to an intestinal intraepithelial lymphoma-carrying driver JAK1 or STAT3 mutations. However, it remains unclear whether these can be safely targeted for therapy. In RCD1, pathogenic insights are still lacking. METHODS: Duodenal...

Topics

Join the communities discussing this publication.

Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.

Abstract excerpt

Topics

Discuss the evidence

Related research