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Article

Single-Cell Analysis of Refractory Celiac Disease Demonstrates Inter- and Intra-Patient Aberrant Cell Heterogeneity

1 Jan 2022

Abstract excerpt

Background & Aims Refractory celiac disease type II (RCDII) is a rare indolent lymphoma in the small intestine characterized by a clonally expanded intraepithelial intracellular CD3 + sCD3 - CD7 + CD56 - aberrant cell population. However, RCDII pathogenesis is ill-defined. Here, we aimed at single-cell characterization of the innate and adaptive immune system in RCDII. Methods Paired small intestinal and blood...

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PMID: 35338007
DOI: 10.1016/j.jcmgh.2022.03.005

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