Article
Expanded T cell clones with lymphoma driver somatic mutations accumulate in refractory celiac disease.
Science translational medicine - 14 May 2025
Singh Mandeep, Louie Raymond H Y, Samir Jerome, Field Matthew A, Milthorpe Claire, Adikari Thiruni, Mackie Joseph, Roper Ellise, Faulks Megan, Jackson Katherine J L, Calcino Andrew, Hardy Melinda Y, Blombery Piers, Amos Timothy G, Deveson Ira W, Wende Helen Vander, Floor Stephen N, Read Scott A, Shek Dmitri, Guerin Antoine, Ma Cindy S, Tangye Stuart G, Di Sabatino Antonio, Lenti Marco V, Pasini Alessandra, Ciccocioppo Rachele, Ahlenstiel Golo, Suan Dan, Tye-Din Jason A, Goodnow Christopher C, Luciani Fabio
Abstract excerpt
Intestinal inflammation continues in a subset of patients with celiac disease despite a gluten-free diet. Here, by applying multi-omic single-cell analysis to duodenal biopsies, we found that low-grade malignancies with lymphoma driver mutations in patients with refractory celiac disease type 2 (RCD2) are comprised by surface CD3-negative (sCD3-) lymphocytes stalled at an innate lymphoid cell (ILC)-progenitor T...
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