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CLONAL LYMPHOCYTE EXPANSIONS AND JAK-STAT PATHWAY MUTATIONS DEFINE A PATHOGENIC CONTINUUM DRIVING RESISTANCE TO GLUTEN-FREE DIET IN CELIAC DISEASE

2025-09-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background&Aims</h4> Despite recent advances, refractory celiac disease (RCD) poses challenging questions. In type 2 RCD (RCD2), the lack of response to the gluten-free diet is attributed to an intestinal intraepithelial lymphoma carrying driver JAK1 or STAT3 mutations. However, it remains unclear whether these can be safely targeted for therapy. In RCD1, pathogenic insights are still lacki...

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Literature Corpus work: a3999624-b569-5b2a-b6c7-4e718ba915a8
DOI: 10.1101/2025.08.27.672584

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