4D force patterning enables spatial control of angiogenesis

Abstract excerpt

Engineering organized microvascular networks remains a critical challenge in tissue engineering and regenerative medicine. While biochemical approaches for patterning angiogenesis via growth factor delivery have shown promise, their inability to pattern sustained growth factors with spatiotemporal control limits effectiveness. Here, we demonstrate that dynamically patterned mechanical forces enable precise spatiot...

Topics

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• Biocompatible Materials
• Cellular Microenvironment
• Elastic Modulus
• Extracellular Matrix
• Human Umbilical Vein Endothelial Cells
• Lab-On-A-Chip Devices
• Neovascularization, Physiologic
• Phenotype

Identifiers and source

Literature Corpus work

b01789f3-6032-5036-8b7b-ce6097a7916c

DOI

10.1101/2025.11.11.687921