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Article

Microtopographical cues in 3D attenuate fibrotic phenotype and extracellular matrix deposition: implications for tissue regeneration.

Tissue engineering. Part A - 1 Aug 2010

Ayala Perla, Lopez Jose I, Desai Tejal A

Abstract excerpt

Recent studies have highlighted the role of external biophysical cues on cell morphology and function. In particular, substrate geometry and rigidity in two dimensions has been shown to impact cell growth, death, differentiation, and motility. Knowledge of how these physical cues affect cell function in three dimensions is critical for successful development of novel regenerative therapies. In this work, the...

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Identifiers

PMID: 20235832
DOI: 10.1089/ten.TEA.2009.0815
PMCID: PMC2947433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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