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Article

β1 integrin is a sensor of blood flow direction

2019-01-03

Abstract excerpt

<h4>ABSTRACT</h4> The ability of endothelial cells (EC) to sense blood flow direction is a critical determinant of vascular health and disease. Unidirectional flow induces EC alignment and vascular homeostasis, whereas bidirectional flow has pathophysiological effects. EC express several mechanoreceptors that can respond to fluid flow (shear stress) but the mechanism for sensing the direction of shearing force is...

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Literature Corpus work
34aedaf0-3ed2-5260-aadb-1fb10749aef3
DOI
10.1101/511261
Open publication

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β1 integrin is a sensor of blood flow directionDOI 10.1101/511261
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