Article

Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes

2020-05-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In vitro , animal model, and clinical evidence suggests that tuberculosis is not a monomorphic disease, and that host response to tuberculosis is protean with multiple distinct molecular pathways and pathologies (endotypes). We applied unbiased clustering to identify separate tuberculosis endotypes with classifiable gene expression patterns and clinical outcomes. <h4>Methods</...

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Literature Corpus work: b0021c70-24fc-5911-a9d9-d0d25aadd771
DOI: 10.1101/2020.05.13.20100776

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