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Gene Set Enrichment Analysis Reveals Individual Variability in Host Responses in Tuberculosis Patients

4 Aug 2021

Abstract excerpt

Group-aggregated responses to tuberculosis (TB) have been well characterized on a molecular level. However, human beings differ and individual responses to infection vary. We have combined a novel approach to individual gene set analysis (GSA) with the clustering of transcriptomic profiles of TB patients from seven datasets in order to identify individual molecular endotypes of transcriptomic responses to TB. We...

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PMID: 34421903
DOI: 10.3389/fimmu.2021.694680

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