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Article

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection.

Nature communications - 19 Jun 2018

Singhania Akul, Verma Raman, Graham Christine M, Lee Jo, Tran Trang, Richardson Matthew, Lecine Patrick, Leissner Philippe, Berry Matthew P R, Wilkinson Robert J, Kaiser Karine, Rodrigue Marc, Woltmann Gerrit, Haldar Pranabashis, O'Garra Anne

Abstract excerpt

Whole blood transcriptional signatures distinguishing active tuberculosis patients from asymptomatic latently infected individuals exist. Consensus has not been achieved regarding the optimal reduced gene sets as diagnostic biomarkers that also achieve discrimination from other diseases. Here we show a blood transcriptional signature of active tuberculosis using RNA-Seq, confirming microarray results, that...

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Identifiers

PMID: 29921861
DOI: 10.1038/s41467-018-04579-w
PMCID: PMC6008327

Genes

IFNG
TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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