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Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures

23 Apr 2019

Abstract excerpt

BACKGROUND: The World Health Organization (WHO) and Foundation for Innovative New Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum-based diagnostic tests for the diagnosis of active tuberculosis (ATB) disease and for predicting the progression from latent tuberculosis infection (LTBI) to ATB. A large number of host-derived blood-based gene-expression biomarkers for diagnosis...

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PMID: 31013272
DOI: 10.1371/journal.pmed.1002786

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