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Fitness trade-off and the discovery of a novel missense mutation in the PmrB sensor kinase of a colistin-resistant <i>Pseudomonas aeruginosa</i> strain developed by adaptive laboratory evolution

2024-11-01

Abstract excerpt

Pseudomonas aeruginosa is a prominent bacterial pathogen that causes several nosocomial infections and is notorious for its environmental resilience and rapid development of resistance to frontline antibiotics. A major cause of mortality and morbidity among cystic fibrosis patients, multidrug-resistant P. aeruginosa is often targeted with the antibiotic colistin as a last option. However, increasing reports of co...

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Literature Corpus work
aff584bb-27d6-5e54-bc2e-fcc1c1652bff
DOI
10.1101/2024.10.31.621426
Open publication

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Fitness trade-off and the discovery of a novel missense mutation in the PmrB sensor kinase of a colistin-resistant <i>Pseudomonas aeruginosa</i> strain developed by adaptive laboratory evolutionDOI 10.1101/2024.10.31.621426
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