Article

Inhibition of PRMT5 triggers synthetic lethality in ARID1A-deficient endometrial cancer cells by promoting aberrant R-loop accumulation

2025-10-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Endometrial cancer (EC) is a common malignancy of the female reproductive system. The 5-year survival rate for advanced-stage EC patients is less than 20%, highlighting an urgent need for novel therapeutic strategies. ARID1A, a key subunit of the SWI/SNF chromatin remodeling complex, is one of the most frequently mutated genes in EC, presenting a potential av...

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Literature Corpus work: aff04620-3bc6-5c8b-a2bf-3370856f7711
DOI: 10.21203/rs.3.rs-7702632/v1

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