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Article

Explore the alterations of downstream molecular pathways caused by ARID1A mutation/knockout in human endometrial cancer cells.

Journal of cancer research and clinical oncology - 1 Dec 2023

Xing Baoling, Zhang Xiaoying, Gu Xia, Xiang Lintao, Wang Cuiping, Jin Yueling

Abstract excerpt

PURPOSE: As one of the most common gynecologic malignancies, endometrial cancer (EC) is driven by multiple genetic alterations that may be targeted for treatments. AT-rich interaction domain 1A (ARID1A) gene mutations were reported as early events in endometrial carcinogenesis. METHODS: To explore the alterations of downstream molecular pathways caused by ARID1A mutations and the associated therapeutic...

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PMID: 37906351
DOI: 10.1007/s00432-023-05471-x

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