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Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response

19 Sept 2022

Abstract excerpt

Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific chromatin locations by orchestrating and modifying histone complexes. This task is responsible for fundamental cell physiology including transcription, DNA replication, methylation, and damage repair. Aberrations in this activity have emerged as epigenomic mechanisms in...

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PMID: 36123603
DOI: 10.1186/s12929-022-00856-5

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