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Article

ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies

17 Jul 2018

Abstract excerpt

SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members ARID1A and ARID1B as well as the ATPases SMARCA2 and SMARCA4. SWI/SNF complexes are mutated across many cancer types. The highest mutation incidence is found in ARID1A, primarily consisting of...

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PMID: 30025943
DOI: 10.1016/j.bbcan.2018.07.005

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