Back to search

Article

Hypoxia-sensing by the Histone Demethylase UTX ( <i>KDM6A</i> ) Controls Colitogenic CD4 <sup>+</sup> T cell Fate and Mucosal Inflammation

2023-07-29

Abstract excerpt

Hypoxia is a feature of inflammatory conditions [e.g., inflammatory bowel disease (IBD)] and can exacerbate tissue damage in these diseases. To counteract hypoxia’s deleterious effects, adaptive responses have evolved which protect against hypoxia-associated tissue injury. To date, much attention has focused on hypoxia-activated HIF (hypoxia-inducible factor) transcription factors in these responses. However, rece...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c27aceae-b3ba-5106-9791-5a226e8fb20e
DOI
10.1101/2023.07.27.550746
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hypoxia-sensing by the Histone Demethylase UTX ( <i>KDM6A</i> ) Controls Colitogenic CD4 <sup>+</sup> T cell Fate and Mucosal InflammationDOI 10.1101/2023.07.27.550746
RNA binding protein DDX5 restricts RORγt + T reg suppressor function to promote intestine inflammationSemantic proximity
Utx loss causes myeloid transformation.Semantic proximity
Neutrophil Plasticity and De Novo DUOX2 Expression in Inflammatory Bowel Disease Pathogenesis: A Review of Single-Cell Transcriptomic Advances and Therapeutic StrategiesSemantic proximity
Neutrophil Plasticity and De Novo DUOX2 Expression in Inflammatory Bowel Disease Pathogenesis: A Review of Single-Cell Transcriptomic Advances and Therapeutic StrategiesSemantic proximity
The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis PatientsSemantic proximity
The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cellsSemantic proximity
Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal CancerSemantic proximity
The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in MiceSemantic proximity
Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signalingSemantic proximity
The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cellsSemantic proximity
REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREMSemantic proximity
HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammationSemantic proximity
Select a neighboring publication to make it the new centre.