Article

A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

2022-06-13

Abstract excerpt

Schizophrenia results in part from a failure of prefrontal networks but we lack full understanding of how disruptions at a synaptic level cause failures at the network level. This is a crucial gap in our understanding because it prevents us from discovering how genetic mutations and environmental risks that alter synaptic function cause prefrontal network to fail in schizophrenia. To address that question, we deve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a32e89d-bea2-518d-a5af-7ede8bd84250
DOI: 10.1101/2022.06.10.495666

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophreniaDOI 10.1101/2022.06.10.495666Read

A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia.Semantic proximity Read

A Formal Model of Mood Disorders Based on the Neural Circuit Dynamics of the Triple Network ModelSemantic proximity Read

Differential Vulnerability of Stimulus-Locked and Persistent Gamma Oscillations: Implications in SchizophreniaSemantic proximity Read

Simple models of quantitative firing phenotypes in hippocampal neurons: Comprehensive coverage of intrinsic diversity.Semantic proximity Read

Combining theory, model and experiment to understand how theta rhythms are generated in the hippocampusSemantic proximity Read

A network model of the modulation of gamma oscillations by NMDA receptors in cerebral cortexSemantic proximity Read

An E-I Firing Rate Model for Gamma OscillationsSemantic proximity Read

Quantitative firing pattern phenotyping of hippocampal neuron typesSemantic proximity Read

The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in SchizophreniaSemantic proximity Read

Prefrontal broadband noise, working memory, and genetic risk for schizophrenia.Semantic proximity Read

Quantitative firing pattern phenotyping of hippocampal neuron types.Semantic proximity Read

Cell-type specific contributions to theta-gamma coupled rhythms in the hippocampusSemantic proximity Read