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Article

Cholinergic dysfunction alters synaptic integration between thalamostriatal and corticostriatal inputs in DYT1 dystonia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Aug 2012

Sciamanna Giuseppe, Tassone Annalisa, Mandolesi Georgia, Puglisi Francesca, Ponterio Giulia, Martella Giuseppina, Madeo Graziella, Bernardi Giorgio, Standaert David G, Bonsi Paola, Pisani Antonio

Abstract excerpt

Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic interneurons. These neurons respond with a pause in their pacemaking activity, enabling synaptic integration with cortical inputs to medium spiny neurons (MSNs), thus playing a crucial role in motor funct...

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Identifiers

PMID: 22933784
DOI: 10.1523/JNEUROSCI.0041-12.2012
PMCID: PMC3471539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22933784-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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