Article

G4-Ligand Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

2023-09-20

Abstract excerpt

<h4>ABSTRACT</h4> G-quadruplex (G4) DNA structures are prevalent secondary DNA structures implicated in fundamental cellular functions such as replication and transcription. Furthermore, G4 structures are directly correlated to human diseases such as cancer and have been highlighted as promising therapeutic targets for their ability to regulate disease-causing genes, e.g., oncogenes. Small molecules that bind and...

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Literature Corpus work: 3ba9703a-f5ed-5c00-a2e4-e052e0675b19
DOI: 10.1101/2023.09.20.558437

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G4-Ligand Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA StructuresDOI 10.1101/2023.09.20.558437Read

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