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Selective targeting of α <sub>4</sub> β <sub>7</sub> /MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

2023-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Integrin α 4 β 7 + T cells perpetuate tissue injury in chronic inflammatory diseases, yet their role in hepatic fibrosis progression remains poorly understood. Here we report increased accumulation of α 4 β 7 + T cells in the liver of people with cirrhosis relative to disease controls. Similarly, hepatic fibrosis in the established mouse model of CCl 4 -induced liver fibrosis was associated...

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Literature Corpus work
afb4766e-d56c-5e60-8f2b-964c3b77e6bf
DOI
10.1101/2023.02.20.528201
Open publication

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Selective targeting of α <sub>4</sub> β <sub>7</sub> /MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liverDOI 10.1101/2023.02.20.528201
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