Article

MAIT cells exacerbate liver fibrosis by downsizing the intrahepatic regulatory T cell compartment

2026-04-19

Abstract excerpt

<h4>ABSTRACT</h4> Mucosa-associated invariant T (MAIT) cells have been paradoxically implicated in both tissue repair and fibrosis. However, when and how they modulate fibrogenesis in the injured liver remain unclear. Here, using the carbon tetrachloride-induced model of liver injury in MR1- and MAIT cell-sufficient and -deficient mice, we identify MAIT cells as an early driver of fibrogenesis. The presence of MA...

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Literature Corpus work: 2a9650c1-6ef7-5f8f-bd67-b229ff0e0965
DOI: 10.64898/2026.04.15.718691

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