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Article

Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.

The Journal of clinical investigation - 1 Sept 2007

Park Eun Jeong, Mora J Rodrigo, Carman Christopher V, Chen JianFeng, Sasaki Yoshiteru, Cheng Guiying, von Andrian Ulrich H, Shimaoka Motomu

Abstract excerpt

Integrin adhesion molecules mediate lymphocyte migration and homing to normal and inflamed tissues. While the ligand-binding activity of integrins is known to be modulated by conformational changes, little is known about how the appropriate balance of integrin adhesiveness is maintained in order to optimize the migratory capacity of lymphocytes in vivo. In this study we examined the regulation of the gut homing...

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Source

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Identifiers

PMID: 17786243
DOI: 10.1172/JCI31570
PMCID: PMC1952632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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