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Article

Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.

PloS one - 1 Jan 2012

Nellen Andreas, Heinrichs Daniel, Berres Marie-Luise, Sahin Hacer, Schmitz Petra, Proudfoot Amanda E, Trautwein Christian, Wasmuth Hermann E

Abstract excerpt

BACKGROUND: The chemokine CCL5 is involved in the recruitment of immune cells and a subsequent activation of hepatic stellate cells (HSC) after liver injury. We here investigate whether inhibition of CCL5 oligomerization and glycosaminoglycan binding by a mutated CCL5 protein ((44)AANA(47)-CCL5) has the potential to ameliorate liver cell injury and fibrosis in vivo. METHODOLOGY: Liver injury was induced in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22574195
DOI: 10.1371/journal.pone.0036614
PMCID: PMC3344902

Genes

CCL5
CCL3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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