Article

Non-selective beta-blockers reduce bystander CD8 <sup>+</sup> T cell activation in decompensated liver cirrhosis

2025-11-18

Abstract excerpt

Cirrhosis is characterized by immune dysfunction in which activated CD8⁺ T cells fuel systemic inflammation and disease progression. Non-selective beta-blockers (NSBB), widely prescribed for portal hypertension, have incompletely understood immunomodulatory effects. Here we show that CD8⁺ T cells express β2-adrenergic receptors, enriched in bystander relative to antigen-specific subsets. In vitro , the NSBB propr...

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Literature Corpus work: c1bccfeb-d84f-56e2-86d3-d63755732f64
DOI: 10.1101/2025.11.18.688703

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Non-selective beta-blockers reduce bystander CD8 <sup>+</sup> T cell activation in decompensated liver cirrhosisDOI 10.1101/2025.11.18.688703Read

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