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Article

Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144.

Experimental cell research - 1 Feb 2013

Zubeldia Idoia G, Bleau Anne-Marie, Redrado Miriam, Serrano Diego, Agliano Alice, Gil-Puig Carmen, Vidal-Vanaclocha Fernando, Lecanda Jon, Calvo Alfonso

Abstract excerpt

Colorectal cancer (CRC) frequently metastasizes to the liver, a phenomenon that involves the participation of transforming-growth-factor-β(1) (TGFβ(1)). Blockade of the protumorigenic effects elicited by TGFβ(1) in advanced CRC could attenuate liver metastasis. We aimed in the present study to assess the antimetastatic effect of TGFβ(1)-blocking peptides P17 and P144, and to study mechanisms responsible for this...

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Identifiers

PMID: 23153552
DOI: 10.1016/j.yexcr.2012.11.004

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SOX2

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