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Article

Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.

Cancer research - 1 Apr 2012

Vinuesa Amaya G, Sancho Rocío, García-Limones Carmen, Behrens Axel, ten Dijke Peter, Calzado Marco A, Muñoz Eduardo

Abstract excerpt

Neuroinflammation driven by the vanilloid-type ion channel receptor transient receptor potential vanilloid type 1 (TRPV-1) is suspected to play a role in the pathophysiology of inflammatory bowel disease. Because inflammatory bowel disease is known to elevate the risk of colon cancer, we examined postulated roles for TRPV-1-driven neuroinflammation in promoting colitis-associated and spontaneous colon cancer...

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Source

Identifiers

PMID: 22396497
DOI: 10.1158/0008-5472.CAN-11-3693

Genes

APC
STAT3
VIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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