Article

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model

2019-01-29

Abstract excerpt

Inflammatory bowel disease (IBD) is characterized by chronic, recurring inflammation of the digestive tract. Current therapeutic approaches are limited and include biologics and steroids such as anti-TNFα monoclonal antibodies and corticosteroids, respectively. Significant adverse drug effects can occur for chronic usage and include increased risk of infection in some patients. GPR4, a pH-sensing G protein-coupled...

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Literature Corpus work: 32c0fe2e-ad69-5551-8211-772bdf0fcbc6
DOI: 10.1101/533174

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