Article
Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation
16 Jan 2017
Abstract excerpt
Orphan GPCRs provide an opportunity to identify potential pharmacological targets, yet their expression patterns and physiological functions remain challenging to elucidate. Here, we have used a genetically engineered knockin reporter mouse to map the expression pattern of the Gpr182 during development and adulthood. We observed that Gpr182 is expressed at the crypt base throughout the small intestine, where it...
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