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Article

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.

The Journal of clinical investigation - 1 Apr 2002

Kabashima Kenji, Saji Tomomi, Murata Takahiko, Nagamachi Miyako, Matsuoka Toshiyuki, Segi Eri, Tsuboi Kazuhito, Sugimoto Yukihiko, Kobayashi Takuya, Miyachi Yoshiki, Ichikawa Atsushi, Narumiya Shuh

Abstract excerpt

We used mice deficient in each of the eight types and subtypes of prostanoid receptors and examined the roles of prostanoids in dextran sodium sulfate-induced (DSS-induced) colitis. Among the prostanoid receptor-deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-type...

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Identifiers

PMID: 11927615
DOI: 10.1172/JCI14459
PMCID: PMC150928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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