Article

GPR120 Prevents Colorectal Adenocarcinoma Progression by Sustaining The Mucosal Barrier Integrity

2021-06-15

Abstract excerpt

<h4>Background: </h4> &Aims GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by ω-3 PUFAs, and expressed in many cell types. Its role in the context of colorectal cancer (CRC) is still puzzling with many controversial evidences. Here, we explored the involvement of epithelial GPR120 in the CRC development. <h4>Methods: </h4> Both in vitro and in vivo experiments were conducted to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8efe84ca-7950-567a-8036-9a3ed6d43742
DOI: 10.21203/rs.3.rs-598555/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GPR120 Prevents Colorectal Adenocarcinoma Progression by Sustaining The Mucosal Barrier IntegrityDOI 10.21203/rs.3.rs-598555/v1Read

The pivotal role of a novel free fatty acid receptor GPR164 in the intestinal barrier functionSemantic proximity Read

GPR4 knockout attenuates intestinal inflammation and forestalls the development of colitis-associated colorectal cancer in murine modelsSemantic proximity Read

Lactobacillus plantarum Ameliorates Colorectal Cancer by Ameliorating the Intestinal Barrier through the CLA-PPAR-γ AxisSemantic proximity Read

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesisSemantic proximity Read

The gut microbiota at the intersection of bile acids and intestinal carcinogenesis: An old story, yet mesmerizingSemantic proximity Read

Bacterial translocation and barrier dysfunction enhance colonic tumorigenesisSemantic proximity Read

GPR4 Deficiency Alleviates Intestinal Inflammation in a Mouse Model of Inflammatory Bowel DiseaseSemantic proximity Read

Multiple Roles of Toll-Like Receptor 4 in Colorectal CancerSemantic proximity Read

GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal CancerSemantic proximity Read

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibitionSemantic proximity Read

Delineating the role of nuclear receptors in colorectal cancer, a focused reviewSemantic proximity Read

Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1 <sup>+</sup> macrophages regulates the intestinal cytokine milieuSemantic proximity Read