Article

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception

2025-06-15

Abstract excerpt

<h4>Background & Aims</h4> Localised acidification from immune cell infiltration and heightened glycolysis contributes to colitis pathology by activating acid-sensing receptors such as GPR68, a proton-sensing GPCR expressed on immune and stromal cells. Single-cell RNAseq analysis revealed GPR68 is also expressed in colonic sensory neurons, prompting us to investigate its role in acid-induced colonic nociception....

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Literature Corpus work: 6b83c298-c199-56a7-b56d-02b9b3c3a0e1
DOI: 10.1101/2025.06.13.659465

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