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Article

Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice.

The Journal of biological chemistry - 29 Mar 2013

Liu Shijie, Qian Yu, Li Liang, Wei Gaigai, Guan Yuting, Pan Hongjie, Guan Xin, Zhang Long, Lu Xiaoling, Zhao Yongxiang, Liu Mingyao, Li Dali

Abstract excerpt

Lgr4/Gpr48 is one of the newly identified R-spondins receptors and potentiates Wnt signaling, which regulates intestinal homeostasis. We used a hypomorphic mouse strain to determine the role of Lgr4 in intestinal inflammation and recovery. Intestinal inflammation was induced with dextran sulfate sodium (DSS) followed by a recovery period. Intestinal inflammation symptoms and molecular mechanisms were examined. We...

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PMID: 23393138
DOI: 10.1074/jbc.M112.436204
PMCID: PMC3610954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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