Article

Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1 <sup>+</sup> macrophages regulates the intestinal cytokine milieu

2020-02-04

Abstract excerpt

<h4>Summary</h4> Single nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease. However, the mechanism(s) by which GPR35 modulates the intestinal milieu remain undefined. Here we demonstrate in zebrafish and mice that expression of Gpr35 is microbiota-dependent and is enhanced upon inflammation. We identify a GPR35 + c...

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Literature Corpus work: b79a3a39-8ecf-5f9f-8301-1fe7988619e4
DOI: 10.1101/2020.02.03.932186

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